Which agent is a topical carbonic anhydrase inhibitor listed for glaucoma management?

Which agent is a topical carbonic anhydrase inhibitor listed for glaucoma management?

• A. Dorzolamide 2%
• B. Pilocarpine 2%
• C. Timolol
• D. Demecarium bromide

Answer: (A)

Topical carbonic anhydrase inhibitors lower intraocular pressure by reducing aqueous humor production. They block the enzyme carbonic anhydrase in the ciliary body, which decreases bicarbonate formation and ion transport, leading to less fluid moving into the posterior chamber. Dorzolamide 2% is a topical carbonic anhydrase inhibitor used in glaucoma management. The other agents work by different mechanisms: pilocarpine stimulates the iris sphincter to increase outflow, timolol reduces aqueous production as a beta-blocker, and demecarium bromide is a cholinesterase inhibitor that causes miosis and increases outflow but is not a CA inhibitor.

Topical carbonic anhydrase inhibitors lower intraocular pressure by reducing aqueous humor production. They block the enzyme carbonic anhydrase in the ciliary body, which decreases bicarbonate formation and ion transport, leading to less fluid moving into the posterior chamber. Dorzolamide 2% is a topical carbonic anhydrase inhibitor used in glaucoma management. The other agents work by different mechanisms: pilocarpine stimulates the iris sphincter to increase outflow, timolol reduces aqueous production as a beta-blocker, and demecarium bromide is a cholinesterase inhibitor that causes miosis and increases outflow but is not a CA inhibitor.