Phacoclastic uveitis is caused by which event?

Phacoclastic uveitis is caused by which event?

• A. Rupture of lens capsule with rapid loss of lens proteins causing severe inflammation
• B. Phakic intraocular lens dislocation
• C. Chronic low-grade inflammation due to lens aging
• D. Endophthalmitis

Answer: (C)

Phacoclastic uveitis happens when the lens capsule ruptures and lens proteins spill into the anterior chamber. Those proteins are normally sequestered from the immune system, so their release acts as antigens and triggers a rapid, severe intraocular inflammatory response. This is different from aging-related lens changes, which are typically slow and low-grade, and from lens dislocation or infection-related conditions. Endophthalmitis is an infection, not an immune reaction to leaked lens proteins. So the rupture of the lens capsule with rapid loss of lens proteins causing severe inflammation best explains phacoclastic uveitis.

Phacoclastic uveitis happens when the lens capsule ruptures and lens proteins spill into the anterior chamber. Those proteins are normally sequestered from the immune system, so their release acts as antigens and triggers a rapid, severe intraocular inflammatory response. This is different from aging-related lens changes, which are typically slow and low-grade, and from lens dislocation or infection-related conditions. Endophthalmitis is an infection, not an immune reaction to leaked lens proteins. So the rupture of the lens capsule with rapid loss of lens proteins causing severe inflammation best explains phacoclastic uveitis.