How quickly do prostaglandin analogs decrease intraocular pressure?

How quickly do prostaglandin analogs decrease intraocular pressure?

• A. 10-15 minutes
• B. Several hours
• C. Days
• D. Weeks

Answer: (A)

Prostaglandin analogs lower intraocular pressure mainly by increasing uveoscleral outflow. The drop in pressure doesn’t happen instantly; the effect begins within a few hours after a drop is instilled, with meaningful reductions typically seen around 3–6 hours and reaching a fuller effect over the next days to weeks as the outflow pathways remodel. In practice, you can expect roughly a 25–35% reduction from baseline, sustained over the day with daily dosing.

Prostaglandin analogs lower intraocular pressure mainly by increasing uveoscleral outflow. The drop in pressure doesn’t happen instantly; the effect begins within a few hours after a drop is instilled, with meaningful reductions typically seen around 3–6 hours and reaching a fuller effect over the next days to weeks as the outflow pathways remodel. In practice, you can expect roughly a 25–35% reduction from baseline, sustained over the day with daily dosing.